When it comes to improving memory and learning, recent research suggests alpha GPC can be very beneficial. This is because A-GPC transports choline to the brain, stimulating an important neurotransmitter that promotes cognitive health.
Research shows alpha GPC is one of the best nootropic brain supplements on the market. It is a brain-boosting molecule that has been shown to be safe and well tolerated by older patients looking to improve symptoms of dementia, as well as young athletes looking to improve their physical endurance and strength.
Similar to the brain-boosting effects of phosphatidylserine, a-GPC may serve as a natural treatment for Alzheimer's disease and may slow age-related cognitive decline.
What is Alpha GPC?
Alpha GPC or alpha glycerylphosphorylcholine is a molecule that acts as a source of choline. It is a fatty acid found in soy lecithin and other plants and is used in cognitive health supplements and to build muscle strength.
Alpha GPC, also known as choline alfoscerate, is valued for its ability to transport choline to the brain and help the body produce the neurotransmitter acetylcholine, which is responsible for many of choline’s health benefits. Acetylcholine is associated with learning and memory, and it is one of the most important neurotransmitters for muscle contraction.
Unlike choline bitartrate, another popular choline supplement on the market, A-GPC is able to cross the blood-brain barrier. This is why it has promising effects on the brain and why it is used to treat dementia, including Alzheimer's disease.
Alpha GPC benefits and uses
1. Improve memory impairment
Alpha GPC is used to improve memory, learning and thinking skills. It does this by increasing acetylcholine in the brain, a chemical that plays an important role in memory and learning functions. The researchers noted that alpha GPC has the potential to improve cognitive symptoms associated with Alzheimer's disease and dementia.
A double-blind, randomized, placebo-controlled trial published in Clinical Therapeutics in 2003 evaluated the efficacy and tolerability of alpha GPC in the treatment of cognitive impairment caused by mild to moderate Alzheimer's disease.
Patients took 400 mg a-GPC capsules or placebo capsules three times daily for 180 days. All patients were evaluated at the beginning of the trial, after 90 days of treatment, and at the end of the trial 180 days later.
In the alpha GPC group, all assessed parameters, including the cognitive and behavioral Alzheimer's Disease Assessment Scale and the Mini-Mental State Examination, continued to improve after 90 and 180 days of treatment, whereas in the placebo group they remained unchanged. change or worsen.
The researchers concluded that a-GPC is clinically useful and well-tolerated in treating cognitive symptoms of dementia and has potential as a natural treatment for Alzheimer's disease.
2. Promote learning and concentration
There is a wealth of research supporting the benefits of alpha GPC for people with cognitive impairment, but how effective is it for people without dementia? Research shows that Alpha GPC can also improve attention, memory and learning abilities in young healthy adults.
The American Journal of Clinical Nutrition published a cohort study involving participants without dementia and found that higher choline intake was associated with better cognitive performance. Cognitive domains assessed include verbal memory, visual memory, verbal learning, and executive function.
A study published in the Journal of the International Society of Sports Nutrition found that when young adults used alpha GPC supplements, it was beneficial on certain physical and mental performance tasks. Those who received 400 mg of a-GPC scored 18% faster on the serial subtraction test than those who received 200 mg of caffeine. Additionally, the caffeine-consuming group scored significantly higher on neuroticism compared to the alpha GPC group.
3. Improve athletic performance
Research supports the synergistic properties of alpha GPC. For this reason, athletes are increasingly interested in a-GPC due to its potential ability to improve endurance, power output, and muscle strength. Supplementing with a-GPC is known to help increase physical strength, promote the building of lean muscle mass, and shorten post-workout recovery time.
Research shows that alpha GPC increases human growth hormone, which plays a role in cell regeneration, growth and maintenance of healthy human tissue. Growth hormone is known for its ability to enhance physical ability and athletic performance.
There have been many studies evaluating the effectiveness of alpha GPC on physical endurance and strength. A 2008 randomized, placebo-controlled, crossover study involving seven men with resistance training experience showed that a-GPC does affect growth hormone levels. Participants in the experimental group were given 600 mg of alpha GPC 90 minutes before resistance exercise.
The researchers found that compared with baseline, peak growth hormone levels increased 44-fold with alpha GPC and 2.6-fold with placebo. A-GPC use also increased physical strength, with peak bench press force increasing by 14% compared to placebo.
In addition to increasing muscle strength and stamina, growth hormone can promote weight loss, strengthen bones, improve mood, and improve sleep quality.
4. Improve stroke recovery
Early research suggests a-GPC may benefit patients who have had a stroke or transient ischemic attack, known as a "mini-stroke." This is due to alpha GPC's ability to act as a neuroprotectant and support neuroplasticity through nerve growth factor receptors.
In a 1994 study, Italian researchers found that alpha GPC improved cognitive recovery in patients with acute or minor strokes. After stroke, patients received 1,000 mg of alpha GPC by injection for 28 days, followed by 400 mg orally three times daily for the next 5 months.
At the end of the trial, 71% of patients showed no cognitive decline or amnesia, the researchers reported. Additionally, patient scores on the Mini-Mental State Examination improved significantly. In addition to these findings, the percentage of adverse events following use of alpha GPC was low and the researchers confirmed its excellent tolerability.
5. May benefit people with epilepsy
An animal study published in Brain Research in 2017 aimed to evaluate the impact of alpha GPC treatment on cognitive impairment after epileptic seizures. The researchers found that when rats were injected with a-GPC three weeks after induced seizures, the compound improved cognitive function and increased neurogenesis, the growth of nerve tissue.
This study suggests that alpha GPC may be useful in epilepsy patients because of its neuroprotective effects and could potentially ameliorate epilepsy-induced cognitive impairment and neuronal damage.
Alpha GPC and Choline
Choline is an essential micronutrient required for many body processes, especially brain function. It is required for the proper functioning of the key neurotransmitter acetylcholine, which acts as an anti-aging neurotransmitter and helps our nerves communicate.
Although the body makes small amounts of choline on its own, we must obtain the nutrient from food. Some foods high in choline include beef liver, salmon, chickpeas, eggs, and chicken breast. However, some reports suggest that choline from food sources is not properly absorbed by the body, which is why some people suffer from choline deficiency. This is because choline is partially processed in the liver, and people with liver impairment will not be able to absorb it.
This is where alpha GPC supplements come into play. Some experts recommend using choline supplements, such as a-GPC, to enhance brain function and aid memory retention. Alpha GPC and CDP choline are thought to be the most beneficial to the body because they are very similar to the way choline occurs naturally in food. Like choline that is naturally absorbed from the food we eat, alpha GPC is known for its ability to cross the blood-brain barrier when ingested, helping the body convert choline into the all-important neurotransmitter acetylcholine.
Alpha GPC is a potent form of choline. A 1,000 mg dose of a-GPC is equivalent to approximately 400 mg of dietary choline. Or, in other words, alpha GPC is approximately 40% choline by weight.
A-GPC and CDP Choline
CDP Choline, also known as cytidine diphosphate choline and citicoline, is a compound composed of choline and cytidine. CDP Choline is known for its ability to help transport dopamine in the brain. Like alpha GPC, Citicoline is valued for its ability to cross the blood-brain barrier when ingested, giving it memory-enhancing and cognitive-enhancing effects.
While alpha GPC contains approximately 40% choline by weight, CDP choline contains approximately 18% choline. But CDP choline also contains cytidine, a precursor to the nucleotide uridine. Known for its ability to increase cell membrane synthesis, uridine also has cognitive-enhancing properties.
Both a-GPC and CDP choline are known for their cognitive benefits, including their role in supporting memory, mental performance, and concentration.
Where to find and how to use
A-GPC supplements are most commonly used to improve memory and cognitive abilities. It can also be used to improve physical endurance and performance. Alpha GPC is available as an oral dietary supplement. Alpha GPC supplements are easy to find online or from suppliers. You'll find it in capsule and powder forms. Many products containing a-GPC recommend taking the supplement with food to make it most effective.
Suzhou Myland Pharm & Nutrition Inc. is an FDA-registered manufacturer that provides high-quality and high-purity alpha GPC powder.
At Suzhou Myland Pharm we are committed to providing the highest quality products at the best prices. Our alpha GPC powder is rigorously tested for purity and potency, ensuring you get a quality supplement you can trust. Whether you want to support cellular health, boost your immune system or enhance overall health, our alpha GPC powder is the perfect choice.
With 30 years of experience and driven by high technology and highly optimized R&D strategies, Suzhou Myland Pharm has developed a range of competitive products and become an innovative life science supplement, custom synthesis and manufacturing services company.
In addition, Suzhou Myland Pharm is also an FDA-registered manufacturer. The company's R&D resources, production facilities, and analytical instruments are modern and multifunctional, and can produce chemicals from milligrams to tons in scale, and comply with ISO 9001 standards and production specifications GMP.
A-GPC is known to be hygroscopic, meaning it absorbs moisture from the surrounding air. For this reason, supplements need to be stored in airtight containers and should not be exposed to air for extended periods of time.
Final thoughts
Alpha GPC is used to deliver choline to the brain across the blood-brain barrier. It is a precursor to acetylcholine, a neurotransmitter that promotes cognitive health. Alpha GPC supplements can be used to benefit your cognitive health by improving memory, learning, and concentration. Research also shows that a-GPC helps increase physical strength and muscle strength.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Oct-05-2024
