NAD+ (Beta-Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells and is essential for a variety of biological processes, including energy production and DNA repair. As we age, our NAD+ levels decrease, leading to a range of health problems. To combat this problem, many people turn to NAD+ supplements in powder form. However, with so many options out there, determining which NAD+ powder is best for you can be challenging. Choosing the best NAD+ powder requires careful consideration of purity, bioavailability, dosage, clarity, and customer feedback. By prioritizing these factors, you can make an informed decision and choose high-quality NAD+ powder that supports your health and well-being.
NAD occurs naturally in our cells, primarily in their cytoplasm and mitochondria, however, natural levels of NAD decline as we age (every 20 years, in fact), causing the normal effects of aging, Such as decreased energy levels and increased pain and soreness. What's more, aging-related declines in NAD are associated with other age-related diseases, such as cancer, cognitive decline, and frailty.
NAD+ is not a hormone, it is a coenzyme. NAD+ can improve the ability of DNA to repair itself, extend lifespan by reversing the decline of mitochondria, and protect DNA and mitochondrial damage. And can improve chromosome stability. NAD+ is also known as the "miracle molecule" that restores and maintains cell health. In animal studies, it has been confirmed to have strong potential to treat a variety of diseases such as heart disease, diabetes, Alzheimer's disease, and obesity.
NAD+ participates in a variety of biochemical reactions within cells, such as glycolysis, fatty acid oxidation, tricarboxylic acid cycle, respiratory chain, etc. In these processes, NAD+ acts as a hydrogen transmitter, accepting electrons and hydrogen from substrates and then transferring them to Other molecules, such as NADH and FAD, to maintain intracellular redox balance. NAD+ plays a vital role in cellular energy production, free radical protection, DNA repair, and signaling.
In addition, NAD+ is also closely related to aging, and its levels decrease with age. Therefore, maintaining NAD+ levels plays an important role in delaying aging, enhancing energy, promoting cell repair, improving cognitive function, and regulating metabolism.
Notably, aging is accompanied by a progressive decline in tissue and cellular NAD+ levels in a variety of model organisms, including rodents and humans.
Therefore, timely replenishing the NAD+ content in the body can delay aging and ensure health. If you want age to be just a number, supplement NAD+ as early as possible to make you look younger from the inside out.
NAD+ levels decline with age, mainly because its production rate cannot keep up with its consumption rate.
A large number of studies have shown that the decline in NAD+ levels is causally related to many aging-related diseases, including cognitive decline, inflammation, cancer, metabolic diseases, sarcopenia, neurodegenerative diseases, etc.
This is why we need NAD+ supplements. Just like our type 3 collagen, it is constantly being lost.
NAD+ can resist aging. What is the principle behind it?
nad+ activates parp1 gene repair enzyme
Assists DNA repair One of the causes of aging is DNA damage. Your white hair, ovarian and other organ decline, are all related to DNA damage. Staying up late and being stressed will aggravate DNA damage.
Studies have found that NAD+ helps activate the PARP1 gene (which acts as a first responder to detect DNA damage and then promotes the selection of repair pathways. PARP1 leads to the decompression of chromatin structure through ADP ribosylation of histones, and is involved in various DNA repair Factors interact and modify them, thereby improving repair efficiency), thereby repairing DNA damage and promoting the triggering of metabolic shifts.
In summary, NAD+ can directly and indirectly affect many key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cellular senescence, immune cell function, etc., thereby slowing down the human aging process.
NAD+ is the English abbreviation of Nicotinamide adenine dinucleotide. Its full name in Chinese is nicotinamide adenine dinucleotide, or Coenzyme I for short. As a coenzyme that transmits hydrogen ions, NAD+ plays a role in many aspects of human metabolism, including glycolysis, Gluconeogenesis, tricarboxylic acid cycle, etc. Some studies have pointed out that the depletion of NAD+ is related to age, and the physiological mechanisms mediated by NAD+ are related to aging, metabolic diseases, neuropathy and cancer, including regulating cell homeostasis, sirtuins known as "longevity genes", repairing DNA, PARPs family proteins related to necroptosis and CD38 that assists in calcium signaling.
Anti-Aging
Aging refers to the process in which cells irreversibly stop dividing. Unrepaired DNA damage or cellular stress can induce senescence. Aging is generally defined as the process of gradual degradation of physiological functions with age; the external manifestations are physical changes caused by the loss of muscles and bones, and the internal manifestations are reduced basal metabolism and immune function.
Scientists have studied long-lived people, and research results show that there is a gene related to longevity in long-lived people - the "Sirtuins gene". This gene will participate in the repair process of the body's energy supply and DNA replication to maintain the integrity and stability of the gene, remove aging cells, improve the immune system through anti-inflammatory and antioxidant effects, and delay the aging of normal cells.
The only targeted activation of longevity genes "Sirtuins" - NAD+
NAD+ is vital to maintaining body health and balance. Metabolism, redox, DNA maintenance and repair, gene stability, epigenetic regulation, etc. all require the participation of NAD+.
NAD+ maintains chemical communication between the nucleus and mitochondria, and weakened communication is an important cause of cellular aging.
NAD+ can remove the increasing number of erroneous DNA codes during cell metabolism, maintain the normal expression of genes, maintain the normal operation of cells, and slow down the aging of human cells.
Repair DNA damage
NAD+ is an essential substrate for the DNA repair enzyme PARP, which has a significant impact on DNA repair, gene expression, cell development, cell survival, chromosome reconstruction, and gene stability.
Activate longevity protein
Sirtuins are often called the longevity protein family and play an important regulatory role in cell functions, such as inflammation, cell growth, circadian rhythm, energy metabolism, neuronal function, and stress resistance, and NAD+ is an important enzyme for the synthesis of longevity proteins. Activates all 7 longevity proteins in the human body, playing an important role in cellular stress resistance, energy metabolism, preventing cell mutation, apoptosis and aging.
Provide energy
It catalyzes the production of more than 95% of the energy required for life activities. Mitochondria in human cells are the power plants of cells. NAD+ is an important coenzyme in mitochondria to generate the energy molecule ATP, converting nutrients into the energy needed by the human body.
Promote blood vessel regeneration and maintain blood vessel elasticity
Blood vessels are indispensable tissues for life activities. As we age, blood vessels gradually lose their flexibility and become harder, thicker, and narrower, causing "arteriosclerosis." NAD+ can increase the activity of elastin in blood vessels, thereby maintaining the elasticity of blood vessels and maintaining blood vessel health.
Promote metabolism
Metabolism is the sum of various chemical reactions in the body. The body will continue to exchange matter and energy. When this exchange stops, the life of the body will also end.
Professor Anthony and his research team at the University of California, USA, found that NAD+ can effectively improve the slowdown of cell metabolism associated with aging, thereby improving people's health and extending lifespan.
Protect heart health
The heart is the most important organ of human beings, and the NAD+ level in the body plays a crucial role in maintaining the normal operation of the heart. The reduction of NAD+ may be related to the pathogenesis of many cardiovascular diseases, and a large number of basic studies have also confirmed the effect of supplementing NAD+ on heart diseases.
Prevent cardiovascular and cerebrovascular diseases
Studies have shown that almost all seven subtypes of sirtuins (SIRT1-SIRT7) are related to the occurrence of cardiovascular disease. Sirtuins are considered to be agonistic targets for the treatment of cardiovascular diseases, especially SIRT1.
NAD+ is the only substrate for Sirtuins. Timely supplementation of NAD+ to the human body can fully activate the activity of each subtype of Sirtuins, thereby protecting cardiovascular health and preventing cardiovascular diseases.
Promote hair growth
The main cause of hair loss is the loss of hair mother cell vitality, and the loss of hair mother cell vitality is because the NAD+ level in the human body decreases. The hair mother cells do not have enough ATP to carry out hair protein synthesis, thus losing their vitality and leading to hair loss. Therefore, supplementing NAD+ can strengthen the acid cycle and produce ATP, so that the hair mother cells have enough ability to produce hair protein, thereby improving hair loss.
NAD+ cell molecule therapy
As age increases, the level of NAD+ (Coenzyme I) in the body will drop off a cliff, which directly leads to body function and cell aging! After middle age, the level of NAD+ in the human body decreases year by year. At the age of 50, the NAD+ level in the body is only half of that at the age of 20. By age 80, NAD+ levels are only about 1% of what they were at age 20.
So, how is NAD+ powder different from other supplements on the market? Let’s take a closer look at some key points to consider:
1. Bioavailability:
One of the main differences between NAD+ powder and other supplements is its bioavailability. NAD+ powder is easily absorbed by the body and efficiently utilizes coenzymes. Conversely, some other supplements may have lower bioavailability, meaning the body may not be able to absorb and utilize the active ingredients efficiently.
2. Mechanism of action:
NAD+ powder works by replenishing NAD+ levels in the body, thereby supporting various cellular functions. Other supplements may have different mechanisms of action, targeting specific pathways or systems in the body. Understanding the specific mechanisms of action of different supplements can help you determine which ones are best for your individual needs.
3. Research and evidence:
When considering any supplement, it is important to review the existing research and evidence that supports its efficacy and safety. NAD+ powder has been the subject of numerous studies, highlighting its potential benefits for cellular health and longevity. On the other hand, some other supplements may have limited research to support their claims. Understanding the scientific evidence behind a supplement can help you make more informed decisions about its use.
4. Personal needs and goals:
Ultimately, the decision to use NAD+ powder or other supplements should be based on your personal needs and health goals. Consider consulting with a healthcare professional or qualified nutritionist to determine which supplements may be most beneficial to you. Factors such as age, lifestyle, and existing health conditions can all play a role in determining the most appropriate supplement regimen.
NAD+, scientists have been studying it for 100 years. NAD+ is not a brand-new discovery, but a substance that has been studied for more than 100 years.
NAD+ was first discovered in 1904 by British biochemist Sir Arthur Harden, who later won the Nobel Prize in Chemistry in 1929.
In 1920, Hans von Euler-Chelpin isolated and purified NAD+ for the first time and discovered its dinucleotide structure, and then won the Nobel Prize in Chemistry in 1929.
In 1930, Otto Warburg first discovered the key role of NAD+ as a coenzyme in material and energy metabolism, and later won the Nobel Prize in Medicine in 1931.
In 1980, George Birkmayer, a professor at the Department of Medical Chemistry at the University of Graz in Austria, first applied reduced NAD+ to disease treatment.
In 2012, the research group of Leonard Guarente, the research group of world-famous chemist Stephen L. Helfand, and the research group of Haim Y. Cohen respectively discovered that NAD+ can lengthen the rods of Caenorhabditis elegans. The lifespan of nematodes is nearly 50%, it can extend the lifespan of fruit flies by about 10%-20%, and it can extend the lifespan of male mice by more than 10%.
Scientists' exploration and research on life have been constantly updated and iterated. In December 2013, David Sinclair, professor of genetics at Harvard University, published "Supplementing NAD with NAD" in the world's top academic journal "Cell". "After one week of increasing NAD with an agent, the life span of mice was extended by 30%." The research results revealed for the first time that NAD+ supplements can significantly reverse aging and extend life span. This research shocked the world and opened the road to fame for NAD supplements as anti-aging substances. .
With this amazing discovery, NAD+ has established an inseparable connection with anti-aging. In recent years, research on NAD+ has almost dominated the top SCI academic journals such as Science, Nature, and Cell, becoming the most sensational discovery in the medical community. It is said that this It is a historic step taken by mankind in the journey to fight aging and extend life span.
1. Research the brand’s reputation and transparency
When considering a specific NAD+ powder brand, it's worth researching the company's reputation and transparency. Look for brands that prioritize transparency in their sourcing and manufacturing processes. Reputable brands will provide detailed information about their NAD+ powder sourcing, including the quality of the raw materials and the manufacturing standards they adhere to. Additionally, look for customer reviews and testimonials to gauge other users’ overall satisfaction and experience with the brand’s products.
2. Evaluate the purity of NAD+ powder
Purity is a key factor when choosing a NAD+ powder brand. High-quality NAD+ powder should be free of contaminants and fillers, ensuring you get a pure and effective product. Look for brands that conduct third-party testing to verify the purity of their NAD+ powder. Third-party testing provides additional assurance that products meet the highest purity standards and do not contain any harmful substances.
3. Consider manufacturing processes and quality standards
The manufacturing process plays an important role in the quality of NAD+ powder. Choose brands that follow strict quality control measures and adhere to Good Manufacturing Practices (GMP). GMP certification ensures products are produced in a clean and controlled environment, minimizing the risk of contamination and ensuring consistent quality. Additionally, ask about the brand's commitment to sustainability and ethical sourcing practices, as these factors can also reflect on the overall quality of the product.
4. Evaluate the bioavailability and absorption of NAD+ powder
Bioavailability refers to the body's ability to absorb and utilize the active ingredients in a supplement. When choosing a brand of NAD+ powder, consider the bioavailability of the product. Look for brands that utilize advanced delivery systems or technologies to increase NAD+ bioavailability. This can include features such as micronization or encapsulation, which can improve the absorption of NAD+ in the body, ultimately maximizing its effectiveness.
5. Seek scientific research and clinical research
Reputable NAD+ powder brands typically provide scientific and clinical studies to support the efficacy and safety of their products. Look for brands that invest in research and development, as this demonstrates a commitment to producing high-quality and evidence-based products. Scientific validation ensures that NAD+ powder has undergone rigorous testing and evaluation, further confirming its quality and purity.
Suzhou Myland Pharm & Nutrition Inc. has been engaged in the nutritional supplement business since 1992. It is the first company in China to develop and commercialize grape seed extract.
With 30 years of experience and driven by high technology and a highly optimized R&D strategy, the company has developed a range of competitive products and become an innovative life science supplement, custom synthesis and manufacturing services company.
In addition, Suzhou Myland Pharm & Nutrition Inc. is also an FDA-registered manufacturer. The company's R&D resources, production facilities, and analytical instruments are modern and multifunctional and can produce chemicals from milligrams to tons in scale, and comply with ISO 9001 standards and production specifications GMP.
Q:What are NAD+ supplements used for?
A:NAD+ supplement is a nutritional supplement that supplements coenzyme NAD+ (nicotinamide adenine dinucleotide). NAD+ plays an important role in energy metabolism and cell repair within cells.
Q: Do NAD+ supplements really work?
A: Some research suggests NAD+ supplements may help improve cellular energy metabolism and slow down the aging process.
Q:What are the dietary sources of NAD+?
A: Dietary sources of NAD+ include meat, fish, dairy products, beans, nuts and vegetables. These foods contain more niacinamide and niacin, which can be converted into NAD+ in the body.
Q: How do I choose a NAD+ supplement?
A: When choosing NAD+ supplements, it is recommended to first seek advice from a doctor or nutritionist to understand your nutritional needs and health status. In addition, choose a reputable brand, check the product ingredients and dosage, and follow the dosage guidance on the product insert.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Aug-05-2024
