Natural compounds are in increasing demand in today's scientific research and pharmaceutical industries. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), as an important plant-derived compound, has attracted widespread attention due to its significant biological activity. For scientific researchers and enterprises, it is crucial to find reliable suppliers of 7,8-Dihydroxyflavone Powder. The 7,8-Dihydroxyflavone Powder provided by Suzhou Myland has a CAS number of 38183-03-8 and a purity of up to 98%, providing you with a trustworthy choice.
7,8-Dihydroxyflavone (also known as 7,8-DHF or proflavonoid) is a naturally occurring molecule that belongs to the flavonoid class of compounds. Found in leaves of Godmania aesculifolia, Tridax procumbens and primula.
7,8-DHF is an organic compound with the molecular formula C15H10O4. It is soluble in organic solvents and has the characteristic color, odor and taste associated with flavonoid compounds.
7,8-DHF has emerged as a promising nootropic compound. It has demonstrated a range of neuropharmacological effects in preclinical studies, including improving memory, promoting neurogenesis and preventing neurodegeneration.
As a potent and selective small molecule agonist of tropomyosin receptor kinase B (TrkB), proflavin has demonstrated efficacy in animal models against various diseases, including Alzheimer's disease.
Flavonoids are a class of polyphenolic compounds found in a variety of fruits, vegetables, and other plant sources. In recent years, they have received considerable attention due to their antioxidant, anti-inflammatory, and neuroprotective properties.
These compounds have been shown to have beneficial effects on the brain, including enhancing cognitive function and preventing neurodegenerative diseases. 7,8-DHF is one of the most prominent polyphenolic compounds receiving increasing attention as a nootropic. It has been studied for its potential effects on mood, memory, learning, anxiety, and other cognitive functions.
The neurological effects of 7,8-DHF are thought to be mediated by its interaction with specific receptors. It has been found to be TrkA, a receptor involved in nerve growth factor signaling and important for neuronal survival and plasticity.
7,8-DHF acts by regulating the expression of various receptors, including glutamate receptor subunits and BDNF. It also affects synapse formation, energy metabolism, and the release of acetylcholine in certain brain areas.
Research on 7,8-dihydroxyflavone has expanded into its effects on human health, specifically looking at how it mimics the activity of brain-derived neurotrophic factor (BDNF), a protein essential for neuronal survival and function. of protein.
In terms of its uses, 7,8-DHF has been explored for potential applications in the treatment of neurological diseases due to its ability to penetrate the blood-brain barrier.
7,8-Dihydroxyflavone occurs naturally in a variety of plant food sources, including:
●Fruits: apples, berries, grapes and citrus fruits
●Vegetables: onions, kale, broccoli and spinach
●Herbs: Parsley, thyme and oregano
In addition to these natural sources, 7,8-DHF is also available in supplement form for convenient and planned consumption.
Learn about flavonoids
Flavonoids are polyphenolic compounds that play a vital role in plant pigmentation, UV filtering, and disease resistance. They are divided into several subcategories, including flavonols, flavones, isoflavones, flavanones, and anthocyanins. Each subclass has different chemical structures and biological activities, resulting in different health benefits.
What is 7,8-dihydroxyflavone?
7,8-Dihydroxyflavone is a special type of flavonoid that belongs to the flavonoid subclass. Its chemical structure has two hydroxyl groups at positions 7 and 8 of the flavonoid backbone, which is responsible for its unique properties. This compound is found primarily in plants such as dioscorea (yam) and has been studied for its potential neuroprotective effects, anti-inflammatory properties, and cognitive enhancement.
Key Differences Between 7,8-DHF and Other Flavonoids
1. Chemical structure
The most obvious difference between 7,8-DHF and other flavonoids is its chemical structure. Although many flavonoids share a common backbone, the presence of hydroxyl groups at specific positions can significantly affect their biological activity. For example, quercetin, a well-known flavonol, has a different arrangement of hydroxyl groups, which affects its solubility and interaction with biological targets.
2. Biological activity
7,8-DHF has been shown to have unique biological activities compared to other flavonoids. Research shows that it activates the brain-derived neurotrophic factor (BDNF) signaling pathway, which is critical for neuron survival, growth and differentiation. This mechanism is particularly important in the context of neurodegenerative diseases and cognitive decline.
In contrast, other flavonoids such as catechins (found in green tea) and anthocyanins (found in berries) work primarily through antioxidant activity, scavenging free radicals and reducing oxidative stress. Although these properties are beneficial, they may not directly affect neurotrophic factors in the same way that 7,8-DHF does.
3. Bioavailability
Bioavailability refers to the extent and rate at which an active ingredient or active moiety is absorbed and becomes available at the site of action. 7,8-DHF has shown good bioavailability in animal studies, indicating that it can efficiently cross the blood-brain barrier, which is critical for its neuroprotective effects.
In contrast, the bioavailability of other flavonoids can vary widely. For example, although quercetin is widely consumed, its absorption is often limited due to its rapid metabolism. This difference in bioavailability affects the effectiveness of these compounds in achieving desired health outcomes.
7,8-DHF mechanism of action: BDNF regulation and Trkb receptor activation
In terms of mechanism of action, 7,8-DHF is known to promote the production of BDNF (brain-derived neurotrophic factor) by binding to and activating its receptor TrkB. Without getting too technical, this in turn leads to a cascade of cellular activities that are beneficial in maintaining proper neuronal function and promoting neurogenesis.
7,8-DHF’s main mode of action:
(1) Brain-derived neurotrophic factor (BDNF) and its role in neuroplasticity
With the discovery that brain-derived neurotrophic factor (BDNF) expression is reduced in neurodegenerative diseases, particularly Alzheimer's disease (AD), its importance in maintaining and enhancing brain health is becoming increasingly apparent .
BDNF is critical for various neuronal functions as it promotes synaptic transmission, synaptogenesis, and synaptic plasticity through signaling with TrkB receptors. This makes the BDNF-TrkB signaling pathway a promising target for the development of therapeutic interventions aimed at combating neurodegenerative diseases.
(2) Tropomyosin receptor kinase B (Trkb) receptor signaling pathway
The tropomyosin receptor kinase B (TrkB) receptor plays a critical role in mediating the effects of BDNF on neurons. As a transmembrane tyrosine kinase receptor, TrkB is the primary receptor for BDNF and initiates a cascade of intracellular signaling events upon binding to neurotrophic factors.
BDNF activates TrkB to trigger several key intracellular pathways, including phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), and phospholipase Cγ ( PLCγ)-protein kinase C (PKC) pathway. Each of these pathways contributes to a different aspect of neuronal function and well-being.
The PI3K-Akt pathway is critical for promoting neuronal survival and inhibiting apoptosis. BDNF-TrkB signaling activates this pathway to increase cell survival by inhibiting pro-apoptotic factors and stimulating anti-apoptotic factors, thereby ensuring the preservation of healthy neurons.
On the other hand, the MAPK-ERK pathway plays an important role in neuronal differentiation and proliferation. BDNF-TrkB signaling promotes activation of the MAPK-ERK pathway, which in turn supports neuronal maturation and differentiation and their integration into existing neuronal networks.
The PLCγ-PKC pathway is critical for regulating synaptic plasticity, a fundamental process of learning and memory. BDNF-TrkB signaling modulates the activity of this pathway, ultimately leading to changes in synaptic strength and connectivity.
This modulation promotes the adaptation and reorganization of neural circuits in response to new experiences and environmental stimuli.
By acting as a TrkB agonist, 7,8-DHF exerts its nootropic effects mainly by regulating BDNF-related signaling pathways, thereby promoting neurogenesis and enhancing synaptic plasticity.
By mimicking the effects of BDNF, 7,8-DHF helps protect neurons from damage, promotes their survival, and promotes the growth and maintenance of new neuronal connections. This ability to promote neuroplasticity, improve cognitive function, and relieve symptoms of neurological diseases makes 7,8-DHF a promising candidate for drug development and further research.
7,8-DHF Nootropic Benefits: Cognitive Enhancement and Neuroprotection
Regarding its nootropic benefits, 7,8-DHF works through 4 main mechanisms:
Memory consolidation and retrieval: a hippocampus-dependent task
7,8-DHF has been found to enhance memory consolidation and retrieval in a variety of hippocampus-dependent learning and memory tasks in rodent models. These findings suggest that 7,8-DHF may be a promising nootropic, Can be used to improve memory function in healthy individuals and those with memory impairment.
Synaptic plasticity: long-term potentiation and depression
7,8-DHF has been shown to regulate synaptic plasticity by promoting LTP and reducing LTD in the hippocampus. These effects are thought to be mediated by its ability to activate TrkB receptors and subsequently enhance the BDNF signaling pathway. This modulation of synaptic plasticity contributes to the improvements in cognitive function observed following 7,8-DHF administration.
Antioxidant properties: ROS scavenging and lipid peroxidation
7,8-DHF has antioxidant properties as evidenced by its ability to scavenge reactive oxygen species (ROS) and reduce lipid peroxidation. These effects contribute to its neuroprotective effects by alleviating oxidative stress-induced neuronal damage and dysfunction.
Anti-inflammatory effect: regulates microglial activation and cytokine production
In addition to its antioxidant properties, 7,8-DHF has been found to exert anti-inflammatory effects by modulating microglial activation and reducing the production of pro-inflammatory cytokines such as TNF-α and IL-1β. This further contributes to its neuroprotective and nootropic effects by preventing inflammation-mediated neuronal damage.
When looking for a supplier of 7,8-Dihydroxyflavone Powder, you can consider the following aspects:
1. Supplier’s reputation
Choosing a supplier with a good reputation is crucial. You can get a sense of a supplier's reputation by checking customer reviews, industry reports, and professional forums. Suzhou Myland enjoys a good reputation in the industry, with positive customer feedback and widely recognized product quality.
2. Product quality
Ensure that products provided by suppliers comply with international standards and quality control requirements. Suzhou Myland 7,8-Dihydroxyflavone Powder has undergone strict quality testing and has a purity of up to 98%, ensuring the product's efficiency and safety.
3. Certification and Compliance
Choosing a supplier with GMP (Good Manufacturing Practice) and ISO certification ensures that its production process meets international standards. Suzhou Myland strictly follows these standards to ensure the stability and consistency of each batch of products.
4. Technical support and services
A reliable supplier should provide professional technical support and customer service. Suzhou Myland has a professional technical team that can provide customers with product usage suggestions and technical guidance to help customers achieve better results in research and application.
5. Price and delivery time
Price and delivery time are also important considerations when choosing a supplier. You can request quotes from multiple suppliers and compare their prices and delivery times to find the most suitable option. Suzhou Myland
provides competitive prices and flexible delivery times while ensuring product quality.
How to Get 7,8-Dihydroxyflavone Powder
If you are looking for high quality 7,8-Dihydroxyflavone Powder, Suzhou Myland is your ideal choice. You can contact us by:
Official website: Visit the official website of Suzhou Myland to learn more about product information and technical support.
Online consultation: Communicate directly with our customer service team through the online consultation function provided by the website to obtain the product information and quotations you need.
Telephone contact: Call our contact number to communicate with professional sales staff and obtain detailed product information and purchasing suggestions.
Email inquiry: You can also ask us for product information via email, and we will reply to you as soon as possible.
Finding reliable 7,8-Dihydroxyflavone Powder suppliers is not easy, but by paying attention to the supplier's reputation, product quality, certification and compliance, technical support and service, as well as price and delivery time, you can make a wise decision. choose. Suzhou Myland is your ideal partner with its high-purity 7,8-Dihydroxyflavone Powder and excellent customer service. We look forward to working with you to explore more application potentials of 7,8-Dihydroxyflavone.
Q:Can proflavin improve learning ability?
A:Yes, proflavin has been shown to enhance learning potential in animal studies by promoting neurogenesis and synaptic connections. It regulates neurotransmitter systems that are critical to the learning process, especially in the hippocampus, a key region of the brain for learning.
Q:Does 7,8-DHF aid cognitive recovery after injury?
A:Yes, preclinical studies suggest that 7,8-DHF may aid cognitive recovery after brain injury by promoting neuroprotection and neuroregeneration. It reduces neuronal death and supports the growth of new neurons, potentially improving cognitive function impaired by trauma or ischemic injury.
Q:What role does 7,8-dihydroxyflavone play in aging-related cognitive decline?
A:Emerging research suggests that 7,8-DHF may slow cognitive decline associated with aging by protecting against oxidative stress and inflammation, common factors in age-related cognitive diseases.
By enhancing BDNF levels and TrkB receptor activation, it helps maintain cognitive resilience, although more human studies are needed to thoroughly explore these effects.
Q:Can 7,8-DHF improve attention and executive function?
A:Preliminary animal studies suggest that 7,8-DHF may improve attention and executive function by enhancing neurotransmitter regulation and neural connections in brain regions involved in these processes.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Oct-16-2024
