Today, as the average life expectancy of people around the world is gradually increasing, anti-aging has become a crucial topic. Recently, Urolithin A, a term that was little known in the past, has gradually come into public view. It is a special substance metabolized from intestinal microorganisms and is closely related to health. This article will unveil the mystery of this miraculous natural substance - urolithin A.
The history of urolithin A (UA) can be traced back to 2005. It is a metabolite of intestinal microorganisms and cannot be directly supplemented through dietary channels. However, its precursor ellagitannins are rich in various fruits such as pomegranates and strawberries.
The role of urolithin A
On March 25, 2016, a major study in the magazine "Nature Medicine" drew the audience's attention to its connection with delaying human aging. Since it was discovered in 2016 that UA can effectively extend the life span of C. elegans, UA has been used at all levels (hematopoietic stem cells, skin tissue, brain (organs), immune system, individual life span) and in various species (C. elegans, melanogaster The anti-aging effects have been strongly demonstrated in fruit flies, mice, and humans.
(1) Anti-aging and enhance muscle function
A randomized clinical trial published in JAMA Network Open, a subsidiary journal of the Journal of the American Medical Association, showed that for the elderly or people who have difficulty moving due to illness, UA supplements may help improve muscle health and perform required exercises.
(2) Assist in enhancing the anti-tumor ability of immunotherapy
In 2022, the research team of Florian R. Greten from the Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics in Germany discovered that UA can induce mitophagy in T cells, promote the release of PGAM5, activate the Wnt signaling pathway, and promote T memory stem cells. formation, thereby promoting anti-tumor immunity.
(3) Reverse the aging of hematopoietic stem cells and immune system
In a 2023 study, the University of Lausanne in Switzerland studied its effect on the hematopoietic system by allowing 18-month-old mice to consume urolithin A-rich food for 4 months and monitoring changes in their blood cells monthly. Influence.
The results showed that the UA diet increased the number of hematopoietic stem cells and lymphoid progenitor cells, and decreased the number of erythroid progenitor cells. This finding suggests that this diet may reverse some of the changes in the hematopoietic system associated with aging.
(4) Anti-inflammatory effect
The anti-inflammatory activity of UA is more powerful and can significantly inhibit a variety of typical inflammatory factors such as TNF-α. It is precisely for this reason that UA plays a role in various inflammatory treatments including brain, fat, heart, intestinal and liver tissues. It can relieve inflammation in various tissues.
(5) Neuroprotection
Some scholars have confirmed that UA can inhibit the mitochondria-related apoptosis pathway and regulate the p-38 MAPK signaling pathway, thereby inhibiting oxidative stress-induced apoptosis. For example, UA can improve the survival rate of neurons stimulated by oxidative stress and has a good neuroprotective function.
(6) Effect of fat
UA can affect cellular lipid metabolism and lipogenesis. Studies have shown that UA can induce the activation of brown fat and browning of white fat, while preventing fat accumulation caused by diet.
(7) Improve obesity
UA can also reduce the accumulation of fat in adipocytes and liver cells cultured in vitro and increase fat oxidation. It can convert the less active T4 in thyroxine into the more active T3, enhancing metabolic rate and heat production through thyroxine signaling. , thus playing a role in controlling obesity.
(8) Protect eyes
The mitophagy inducer UA can reduce oxidative stress in aged retina; it reduces the level of cytosolic cGAS and reduces glial cell activation in aged retina.
(9) Skin care
Among all found mammalian intestinal metabolites, UA has the strongest antioxidant activity, second only to proanthocyanidin oligomers, catechins, epicatechin and 3,4-dihydroxyphenylacetic acid. wait.
Urolithin A application scenarios
In 2018, UA has been designated by the US Food and Drug Administration as an edible substance "generally recognized as safe" and can be added to protein shakes, meal replacement drinks, instant oatmeal, nutritional protein bars and milk drinks (up to 500 mg/serving) ), Greek yogurt, high-protein yogurt and milk protein shakes (up to 1000 mg/serving).
UA can also be added to skin care products, including day creams, night creams and serum combinations, designed to enhance skin hydration and significantly reduce wrinkles, improve skin texture from the inside out, and effectively combat the visible signs of aging. , helping skin stay young.
Urolithin A production process
(1) Fermentation process
The commercial production of UA is first achieved through fermentation technology, which is mainly fermented from pomegranate peels and has a urolithin A content of more than 10%.
(2) Chemical synthesis process
With the continuous innovation and development of research, chemical synthesis is an important means of industrial production of urolithin A. Suzhou Myland Pharm is an innovative life science supplement, custom synthesis and manufacturing services company that can provide High-purity, large-volume urolithin A powder raw material.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Aug-23-2024
