In today's nutrition and biomedical research, spermidine, as an important polyamine compound, has gradually attracted widespread attention. Spermidine plays a key role in cell growth, proliferation and aging, and has multiple biological activities such as antioxidant, anti-inflammatory and promoting cell autophagy. In order to meet the market demand for high-quality spermidine, it is particularly important to choose a reliable supplier.
Spermidine occurs naturally in the human body. It is a standard polyamine found in tissues and in human foods such as bell peppers, mushrooms, and wheat germ, which is often found in wheat germ.
It is found in large quantities in soy products such as amaranth seeds and shiitake mushrooms. A diet rich in spermidine will increase your spermidine intake. Still, the best way is to use a supplement.
The key to vitality is relatively simple and lies in a lifestyle that includes regular exercise and a healthy diet. However, longevity supplements such as spermidine can enhance the benefits of a healthy lifestyle.
Longevity supplements work on different pathways in the body to slow the aging process, rather than just providing nutrients to prevent vitamin deficiencies.
Effects of spermidine on the body
Unlike traditional dietary supplements that prevent nutritional deficiencies, spermidine uses active ingredients to act on different molecular pathways in the body that affect aging. Aging is defined as the collection of damage that changes the body over time.
These changes are also known as the "hallmarks of aging," which consist of major hallmarks of damage. These antagonistic features respond to damage and result in a combination of features that lead to the aging phenotype.
Longevity supplements work by controlling the hallmarks of aging, not the effects of aging.
Spermidine improves hallmarks of aging by inducing autophagy, a function of cellular regeneration. It acts as a caloric regulation mimetic (CRM), mimicking the effects of fasting in vivo.
This generates autophagy via the TOR kinase pathway, which regulates cellular metabolism and balances available nutrients when cells are under nutrient stress.
During the autophagy process, cells utilize damaged organelles to complete cellular renewal, which is thought to have many anti-aging benefits.
Spermidine is a unique amino acid and an extremely interesting nutritional factor that can be used for anti-aging. It also plays an important role in cells throughout the body.
Spermidine reverses the aging process through a variety of biological mechanisms. The main ones include the autophagy process and mitochondria (the place where cells produce energy), which is the key factor in producing significant anti-aging effects.
An approach that would put these effects into practice would be to incorporate a spermidine-rich diet or spermidine supplementation as an anti-aging strategy.
Maintaining spermidine levels may help extend lifespan in aging models and animal studies. The levels of spermidine and its metabolite spermine in the blood of people aged 60 to 80 are lower than those under 50. Interestingly, however, the levels of spermidine and its metabolites in people over 90 are similar to those under 50. This finding suggests a correlation between higher spermidine levels and longer lifespan.
What are the effects of spermidine?
Supports cell function
Plays a vital role in cell function and cell survival. Cells need it to activate key molecules involved in:
Cell growth
DNA stability
●Transcription of genetic information
●Produce human protein
● Strengthen the immune system
Spermidine also plays an important role in the immune response and antioxidant system, especially in protecting membrane lipids and DNA.
Promote metabolic function
Spermidine also activates the "master switch" of metabolism, an enzyme called AMP-activated protein kinase (AMPk). AMPk activity plays an important role in energy metabolism and is also associated with life expectancy. As we age, the ability of cells to activate AMPk decreases, leading to insulin resistance, impaired liver function, abdominal (visceral) fat accumulation, and decreased muscle mass (muscle loss). Activating AMPk may be the key to spermidine's anti-aging effect.
Continuous anti-aging
However, most studies have focused on the anti-aging effects of spermidine as a promoter of autophagic process and mitochondrial function.
What is Autophagy?
Autophagy translates to "self-eating". It is a cellular cleanup process during which accumulated cellular waste is transported to compartments in the cell called lysosomes to be broken down or potentially reused.
Autophagy is a cellular quality control process that disposes of cellular waste, debris, microorganisms, unwanted compounds, and biodegradable compounds.
The longevity effect of spermidine
Enhanced autophagy has been found in extremely healthy centenarians and appears to be a key goal for living a healthier, longer life. Genetics play a major role in autophagy, but diet, lifestyle, and dietary supplements also have a strong influence on the expression of autophagy genes. Spermidine is emerging as a key dietary factor for enhancing autophagy.
Spermidine enhances autophagy by acting on various genes that promote autophagy, including the autophagy gene (ATG5). People who overexpress this gene may live longer. ATG5 expression is reduced in conditions of oxidative and free radical damage and reduced mitochondrial function. Therefore, spermidine appears to reverse the effects of these factors on the control of autophagy.
In addition to experimental studies showing that spermidine intake can extend life, there are also human studies showing that higher spermidine intake is associated with lower overall mortality.
In other words, higher spermidine intake may increase lifespan, meaning people can live longer and healthier. Spermidine also protects against aging, especially in the brain, heart, liver, joints, and muscles. These tissues are particularly susceptible to the harmful effects of aging. By increasing autophagy, spermidine may combat aging in these and other tissues.
Impaired autophagy accelerates aging by increasing oxidative damage. It also leads to uncontrolled cellular protein construction, reduces cellular energy production by controlling mitochondrial function, and causes other biochemical challenges associated with accelerated cellular aging. These problems affect every tissue in the body, especially the brain, which is a very metabolically active tissue. Age-related declines in autophagy are also responsible for sarcopenia—the progressive loss of muscle mass and strength associated with age.
One of the keys to helping the body deal with cellular debris is preventing them from forming and accumulating in the first place. Chronic, low-grade inflammation is a hallmark of accelerated aging in humans. This process is called inflammaging, and inflammation can also lead to decreased autophagy.
There are several factors that can trigger an inflammatory response, such as poor blood sugar control and a lack of key dietary factors that mitigate inflammation, such as foods rich in polyphenols, such as berries, other fruits, green leafy vegetables, and vegetables rich in carotenoids.
As inflammation develops, mitochondrial function decreases, primarily due to damage and stress from free radicals and prooxidants. This causes the cell itself to build up more cellular garbage. Therefore, the term "garbage aging" has been used to describe the effects of excessive cellular garbage accumulation, reduced autophagy, or both. Spermidine is both an antioxidant and enhances autophagy, so it may help prevent garbage aging.
Food Sources of Spermidine
Spermidine is found in many foods, but in small amounts. Wheat germ, whole grains, beans, soy foods, and mushrooms are particularly high in spermidine. Aged cheeses, fermented foods, and chicken or beef liver are also good sources of spermidine.
It is estimated that the daily intake of spermidine for adults is about 12.5 mg. Three tablespoons of wheat germ provide about 5 mg of spermidine, which is about 40% of the typical daily intake.
In addition to being taken from the diet, spermidine is also formed in the body. One way it is obtained is through putrescine, a metabolite of ornithine. This pathway involves the conversion of putrescine into spermidine by spermidine synthase. Spermidine can be converted into spermine and then back into spermidine. Although spermidine, spermine and putrescine can be converted into each other, spermidine is the most important and critical polyamine in the physiological processes of human cells.
Intestinal bacteria can also produce spermidine and other polyamines. Since not all intestinal bacteria produce polyamines, different microbiota compositions may favor spermidine production. In the intestinal mucosa, spermidine has multiple beneficial effects, including extending cell lifespan, repairing injured intestinal epithelium, and optimizing cellular energy.
Myland Nutraceuticals Inc. is a company that focuses on the research and development and production of dietary supplement raw materials, and is committed to providing customers with high-purity Spermidine. The CAS number of this product is 124-20-9, and the purity is as high as 98%, ensuring its reliability and effectiveness in various applications.
Features
High purity: Myland Nutraceuticals Inc.'s Spermidine has a purity of 98%, which means that users can get more accurate and consistent results during use. High-purity products can effectively reduce the impact of impurities on the body and ensure the safety and effectiveness of supplements.
Quality Assurance: As an experienced dietary supplement raw material company, Myland Nutraceuticals Inc. strictly follows international standards for production and quality control. Each batch of products undergoes rigorous testing to ensure that they meet relevant quality standards. Customers can use them with confidence and reduce the risk of product quality issues.
Multiple biological activities: Spermidine plays a variety of important functions in cells, including promoting cell proliferation, regulating gene expression, and protecting cells from oxidative stress. Studies have shown that Spermidine can promote cell health and growth by regulating intracellular signaling pathways.
Wide application: Spermidine has a wide range of applications in health products, drug development and basic research. It can not only be used as a nutritional supplement, but also can be used to improve cell function and promote health.
Application Areas
Spermidine supplements have a wide range of applications in a variety of areas:
Anti-Aging Research: As we age, polyamine levels in the body gradually decline. Supplementation with Spermidine is believed to help slow the aging process, improve cell function, and promote health.
Cell biology research: Spermidine plays an important role in cell proliferation and differentiation and is widely used in the research of cell biology and molecular biology.
Where to buy
Myland Nutraceuticals Inc. provides a convenient online purchasing channel, where customers can place orders directly through the official website. In addition, the company's professional team will also provide technical support and consulting services to customers to help them better understand and use the products.
In conclusion
When looking for high-quality Spermidine, Myland Nutraceuticals Inc. is undoubtedly a trustworthy choice. With its high purity, strict quality control and wide application prospects, Myland Nutraceuticals Inc.'s products can meet the various needs of scientific researchers and enterprises. Whether conducting basic research or developing new products, choosing Myland Nutraceuticals Inc.'s Spermidine will give you high-quality protection and support.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Jan-07-2025
