What do you need to know about palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that has attracted attention for its potential health benefits. This compound is found in various tissues throughout the body, and research suggests that palmitamideethanol (PEA) may alleviate inflammation, reduce pain, and may also promote intestinal health and delay aging. It may have a variety of health benefits. The following content will explore the health benefits of  palmitoylethanolamide (PEA), how it works on the human body, and how to find high-quality  palmitoylethanolamide (PEA).

What is palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) is a naturally occurring endocannabinoid-like compound known for its chronic analgesic and anti-inflammatory properties. In addition to being synthesized by the body, PEA is found in a variety of foods including: cheese, egg yolks, meat, milk, peanuts, soy lecithin.

did you know? When the body encounters stressors, such as injury or inflammation, PEA levels adjust to maintain cellular homeostasis.

How does palmitoylethanolamide  affect the human body?

Scientists do not yet fully understand the mechanism of action of palmitoylethanolamide . Nonetheless, we have come a long way, thanks to Professor Rita Levi-Montalcini, who in 1992-1996 elucidated the general mechanism of action of palmitoylethanolamide . Since then, she has continued to study the effects of palmitoylethanolamide  on neuropathic pain and allergies.

Palmitoylethanolamide  may bring four major health benefits to humans:

●Relieve inflammatory response.

●Reduce mast cell activation (allergy).

●Strengthen the activity of endogenous hemp system.

●Activate specific receptors in the body.

How does PEA exert its anti-inflammatory and analgesic effects?

Health benefits of PEA include effects on immune cells that control inflammation, especially in the brain. PEA may help reduce the production of inflammatory substances. However, PEA mainly acts on receptors on cells, which control various aspects of cell function. These receptors are called PPARs. PEA and other compounds that help activate PPAR can reduce pain and can also increase metabolism by burning fat, lower serum triglycerides, increase serum HDL cholesterol, improve blood sugar control, and aid weight loss.

Palmitoylethanolamide  Benefits

Due to its analgesic and anti-inflammatory effects, research suggests that PEA may help with a variety of pain-related conditions, such as fibromyalgia, sciatica, and osteoarthritis.

1. Relieve pain and inflammatory response

Chronic pain is a serious problem that plagues patients around the world, and as the population ages, this problem will become more and more significant. One of the functions of palmitoylethanolamide  is that it may help relieve pain and inflammation. palmitoylethanolamide interacts with CB1 and CB2 receptors, which are important components of the endogenous hemp system. This system is responsible for maintaining homeostasis or balance in the body.

When an injury or inflammatory response occurs, the body releases endogenous hemp compounds to help control the immune response. palmitoylethanolamide may help increase endogenous hemp levels in the body, thereby relieving pain and inflammation.

Additionally, palmitoylethanolamide may reduce the release of inflammatory chemicals and reduce overall neurological inflammatory responses. These effects make palmitoylethanolamide a potential tool to help control pain and inflammatory responses. Studies show that palmitoylethanolamide may also be effective for sciatica pain and carpal tunnel syndrome.

2. Fibromyalgia

Several studies suggest that PEA may help reduce symptoms of fibromyalgia, a chronic neurological disease that causes widespread pain. When used as an adjunct to traditional therapies, PEA ingestion reduces pain intensity and improves quality of life over time. According to one study, taking PEA for three months significantly reduced pain in people with fibromyalgia.

3. Back pain

Preliminary research points to the potential efficacy of PEA for back pain. A 2017 observational study showed that PEA further reduced pain intensity in patients with failed back surgery syndrome.

People who suffer from sciatica, a pain that extends from the lower back down one or both legs, may also find relief after taking PEA. A randomized, double-blind, placebo-controlled trial studied the effects of high- and low-dose PEA versus placebo. Pain was reduced by more than 50% in the high-dose group. Although low-dose PEA did not achieve the same degree of pain relief as high-dose, both doses were significantly more effective than placebo.

4. Osteoarthritis

PEA may be beneficial for people with osteoarthritis, a disease characterized by the degeneration of joint cartilage and bone. Participants in one study who received PEA experienced significant improvements in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores compared with the placebo group. The WOMAC is a questionnaire designed to assess the condition and symptoms (e.g., pain, stiffness, physical function) in patients with knee and hip osteoarthritis.

Another study involving patients with temporomandibular arthritic (TMJ) pain associated with osteoarthritis showed that PEA supplementation significantly improved pain intensity after 14 days compared with ibuprofen. The group given PEA for 14 days showed significantly greater improvement in maximum mouth opening (a measure of pain relief) than the ibuprofen group.

5. Neuropathic pain

Preliminary case studies and animal testing suggest that PEA may help with neuropathic pain (caused by damage to the nerves that carry messages between the brain and spinal cord), particularly in people with carpal tunnel syndrome, diabetic neuropathy, chemotherapy Individuals with peripheral neuropathy, chronic pelvic pain, and pain associated with stroke and multiple sclerosis. Further clinical trials are needed to determine the efficacy of PEA in resolving neuropathic pain.

6. Healthy Aging

Delaying the aging process is a goal of practical value pursued by many scientists around the world. Palmitoylethanolamide is considered an anti-aging supplement that may help protect cells from oxidative damage, which is the main cause of aging.

When cells are exposed to excessive free radical activity, oxidative reactions can occur, leading to premature cell death. Intake of unhealthy foods, smoking, and other environmental exposures such as air pollution also increase oxidative damage.Palmitoylethanolamide may prevent this damage by removing free radicals and reducing the overall inflammatory response in the body.

Additionally, palmitoylethanolamide ethanol has been shown to potentially stimulate the production of collagen and other essential skin proteins. Therefore, it may reduce the appearance of wrinkles and fine lines, acting as a protector from within the cells.

Suzhou Myland Pharm & Nutrition Inc. is an FDA-registered manufacturer that provides high-quality and high-purity Palmitoylethanolamide (PEA) powder.

At Suzhou Myland Pharm we are committed to providing the highest quality products at the best prices. Our Palmitoylethanolamide (PEA) powder is rigorously tested for purity and potency, ensuring you get a high-quality supplement you can trust. Whether you want to support cellular health, boost your immune system, or enhance overall health, our Palmitoylethanolamide (PEA) powder is the perfect choice.

With 30 years of experience and driven by high technology and highly optimized R&D strategies, Suzhou Myland Pharm has developed a range of competitive products and become an innovative life science supplement, custom synthesis and manufacturing services company.

In addition, Suzhou Myland Pharm is also an FDA-registered manufacturer. The company's R&D resources, production facilities, and analytical instruments are modern and multi-functional, and can produce chemicals from milligrams to tons in scale, and comply with ISO 9001 standards and production specifications GMP.