7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavonoid, a polyphenolic compound found in a variety of plants. Flavonoids are known for their antioxidant properties and play a vital role in plant defense mechanisms. 7,8-Dihydroxyflavone is particularly found in plants such as Godmania aesculifolia and Tridax procumbens.
7,8-Dihydroxyflavone differs from other flavonoids in its ability to mimic the activity of brain-derived neurotrophic factor (BDNF). BDNF is a protein that supports the survival, development, and function of neurons in the brain. It plays a key role in neuroplasticity, the brain's ability to reorganize itself by forming new neural connections. This property of 7,8-DHF opens up multiple avenues of research, especially in the field of neuroscience.
Mechanism of action
The primary mechanism by which 7,8-Dihydroxyflavone exerts its effects is activation of the TrkB (tropomyosin receptor kinase B) receptor. TrkB is a high-affinity receptor for BDNF. When 7,8-Dihydroxyflavone binds to TrkB, it triggers a series of intracellular signaling pathways that promote neuronal survival, growth, and differentiation.
Preclinical studies have shown that 7,8-dihydroxyflavone can mimic BDNF (brain-derived neurotrophic factor) and increase its expression and levels in the hippocampus. In animal models, it has therapeutic potential for several neurological diseases or disorders, namely stroke, depression, and Parkinson's disease. In two different studies, 7,8-dihydroxyflavone has shown significant oral bioavailability and was found to cross the brain-blood barrier (BBB). Because it acts on the nitric oxide signaling pathway and activated TrkB receptor (tropomyosin receptor kinase B)
The neurotrophic factor BDNF mainly transmits signals by binding to specific receptors, thereby affecting the physiological processes of neurons. While 7,8-DHF can simulate the effect of the neurotrophic factor BDNF, the key lies in its interaction mechanism with the BDNF receptor. Studies have shown that 7,8-DHF can bind to the BDNF receptor TrkB and activate downstream signaling pathways.
Specifically, when 7,8-DHF binds to TrkB, it triggers a series of intracellular signal transduction events. This includes activation of protein kinases such as the PI3K/Akt and MAPK/ERK pathways. Activation of these pathways is critical for promoting neuronal survival, growth, and synaptic plasticity. By simulating the activation of these pathways by BDNF, 7,8-DHF helps enhance neuronal adaptability and resistance to external stress.
7,8-DHF also regulates gene expression within neurons. It can affect the transcription of genes related to neurodevelopment, neuroprotection and synapse formation, thereby mimicking the effects of BDNF at the molecular level. This modulation of gene expression further supports the role of 7,8-DHF in promoting neurological health.
7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavonoid with multiple effects. It acts as an agonist for the neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) and protects TrkB-expressing neurons from apoptosis. Brain-derived neurotrophic factor (BDNF) is a protein with neurotrophic effects that is essential for brain formation, learning and memory.
• Neuroprotection: 7,8-DHF is neuroprotective in animal models of Parkinson's disease, supports emotional learning in mice and reverses memory deficits in mouse models of Alzheimer's disease, and can also improve motor function and prolong huntingtin survival time of diseased animal models. BDNF can improve neuroplasticity and neuron survival, help the brain generate new neural connections, repair failing brain cells, and protect healthy brain cells. It is essential for brain formation, learning and memory, and can protect the brain from age-related cognitive impairment. Decline in cognitive abilities and protect against neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
• Regulates neuronal survival: 7,8-DHF can bind to TrkB and activate downstream signaling pathways, such as PI3K/Akt and MAPK/ERK pathways. The activation of these pathways is critical for promoting neuronal survival, growth and synaptic plasticity. important. BDNF is also a neurotrophic factor that can activate intracellular signaling pathways by binding to TrkB receptors and promote the survival and growth of neurons.
• Promote synaptic plasticity: 7,8-DHF can promote the formation and strengthening of synapses by activating TrkB receptors, thereby improving the efficiency of synaptic transmission. BDNF is also thought to promote the formation and strengthening of synapses, thereby increasing the efficiency of synaptic transmission and thereby enhancing learning and memory abilities.
• Effects on learning and memory: 7,8-DHF can improve learning and memory abilities in mice, which may be related to its effects on neuronal survival and synaptic plasticity. BDNF also plays an important role in learning and memory processes by promoting the survival of neurons and the formation of synapses, thereby improving learning and memory abilities.
• Modulates mood: 7,8-DHF has mood-modulating effects, which may be related to its effects on neuronal survival and synaptic plasticity. BDNF is also thought to play a role in emotion regulation by regulating the survival of neurons and the formation of synapses, thereby affecting the expression of emotions.
In summary, 7,8-DHF and BDNF have similar mechanisms of action in neuroprotection, regulating neuronal survival, promoting synaptic plasticity, affecting learning and memory, and regulating emotions.
Suzhou Myland Pharm & Nutrition Inc. is an FDA-registered manufacturer that provides high-quality and high-purity 7,8-Dihydroxyflavone.
At Suzhou Myland Pharm we are committed to providing the highest quality products at the best prices. Our 7,8-Dihydroxyflavone is rigorously tested for purity and potency, ensuring you get a high-quality supplement you can trust. Whether you want to support cellular health, boost your immune system or enhance overall health, our 7,8-Dihydroxyflavone is the perfect choice.
With 30 years of experience and driven by high technology and highly optimized R&D strategies, Suzhou Myland Pharm has developed a range of competitive products and become an innovative life science supplement, custom synthesis and manufacturing services company.
In addition, Suzhou Myland Pharm is also an FDA-registered manufacturer. The company's R&D resources, production facilities, and analytical instruments are modern and multifunctional, and can produce chemicals from milligrams to tons in scale, and comply with ISO 9001 standards and production specifications GMP.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Sep-24-2024
