What Is Salidroside and How Can It Help You?

Salidroside is also known as (4-hydroxy-phenyl)-β-D-glucopyranoside, also known as salidroside and rhodiola extract. It can be extracted from Rhodiola rosea or artificially synthesized. Salidroside is a natural antioxidant that protects nerve cells by scavenging ROS and inhibiting cell apoptosis.

Rhodiola rosea is a perennial herbaceous plant that mainly grows in areas with high cold, dryness, anoxia, strong ultraviolet radiation, and large temperature differences between day and night at an altitude of 1,600 to 4,000 meters. It has extremely strong environmental adaptability and vitality.

Salidroside--Antioxidant

Salidroside is a natural antioxidant that can scavenge reactive oxygen species (ROS), inhibit apoptosis, and protect nerve cells. It can improve the skin's antioxidant defense capabilities by activating intracellular antioxidant enzyme systems, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), etc.

Intracellular calcium overload is one of the main causes of neuronal apoptosis. Rhodiola rosea extract and salidroside can reduce the increase in intracellular free calcium levels induced by oxidative stress and protect human cortical cells from glutamate. and hydrogen peroxide-induced apoptosis. Salidroside can inhibit lipopolysaccharide-induced microglial activation, inhibit NO production, inhibit inducible nitric oxide synthase (iNOS) activity, and reduce TNF-α and IL-1β. , IL-6 levels.

Salidroside inhibits NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) and response regulator of development and DNA damage 1 (REDD1)/mammalian target of rapamycin (mTOR)/p70 ribosome The protein S6 kinase signaling pathway activates the AMP-dependent protein kinase/silent information regulator 1, RAS homologous gene family member A/MAPK and PI3K/Akt signaling pathways.

Benefits of Salidroside

1. Two-way regulating effect: Rhodiola rosea mobilizes all positive factors in the body and has a two-way regulating effect of making up for deficiencies and reducing excess. By regulating the functions of the nervous system, endocrine system and metabolic system, blood sugar, blood lipids, blood pressure and cardiovascular and cerebrovascular functions can be restored to normal levels.

2. Effective regulation of the nervous system: effectively eliminate people's tension, balance the central nervous system, improve sleepiness and irritability, excitement or depression; improve attention and enhance memory. Refresh the brain, reduce error rates, improve work and study efficiency, and prevent Alzheimer's disease.

3. Anti-fatigue: Rhodiola rosea has a cardiotonic effect, which can increase the duration of normal activities of the brain and body and extend the load capacity of brain nerves and body muscles. It has a significant effect on preventing and treating fatigue syndrome and maintaining strong energy and vitality for a long time.

4. Anti-radiation and anti-tumor: Salidroside can effectively increase the transformation rate of T lymphocytes and the activity of phagocytes, enhance immunity, inhibit tumor growth, increase white blood cells, resist microwave radiation, and treat cancer patients after radiotherapy and other It has a very good auxiliary rehabilitation effect for those who are physically weak after illness.

5. Anti-hypoxia: Rhodiola rosea can reduce the body's overall oxygen consumption rate, improve the brain's tolerance to hypoxia, and at the same time increase the oxygen-carrying capacity of the blood, increase the body's disease resistance, and quickly recover diseased tissues.

6. Effect on human smooth muscle: Asthma is caused by smooth muscle spasm. Rhodiola rosea can very effectively relieve smooth muscle spasm and regulate intestinal smooth muscle movement. It has obvious effects on asthma, bronchitis, phlegm, constipation, etc.

7. Effect on rheumatoid arthritis: Arthritis is caused by the three evils of wind, cold, and dampness. A large number of clinical trials have proven that Rhodiola rosea can expel wind, resist cold, and eliminate pain. It especially has obvious effects on joint swelling. Swelling and inhibitory effect.

8. Anti-aging: Rhodiola rosea can delay cell aging, increase the activity of SOD in the body, and inhibit the formation of intracellular lipofuscin and reactive oxygen species. Enhance cell metabolism and synthesis and improve cell vitality. In addition, it also has beauty and skin care effects.

Salidroside & Skin Care Field

In the field of skin care, salidroside can resist ultraviolet damage and remove free radicals produced by mitochondria. Its antioxidant and anti-inflammatory effects can improve skin condition, reduce wrinkles, and make skin look younger.

Rhodiola rosea can reduce acid phosphatase activity and the final decomposition products of lipid peroxide (LPO) by increasing the activity of antioxidant-related enzymes (SOD superoxide dismutase, GSH-Px glutathione peroxidase and CAT) content and MDA content, thereby enhancing the body's ability to scavenge free radicals, reducing the degree of peroxidation of biofilms, and protecting the body's cells and tissues from free radical damage.

Prevent skin photoaging

Salidroside can reduce the degradation of extracellular matrix such as collagen and promote the growth of fibroblasts, thereby enhancing skin elasticity, delaying the occurrence of skin wrinkles, and achieving the purpose of resisting photoaging.

Whitening

Salidroside can reduce melanin synthesis by inhibiting tyrosinase activity. Tyrosinase is the key enzyme for melanin synthesis. Salidroside can bind to tyrosinase and reduce its activity, thereby reducing the production of melanin.

Salidroside can also inhibit melanin synthesis by regulating signaling pathways in melanocytes, such as the MITF signaling pathway. MITF is a key transcription factor in melanocytes, which regulates the expression of melanin synthesis-related enzymes such as tyrosinase. Salidroside can reduce the expression of MITF, thereby reducing melanin synthesis.

Anti-inflammatory

Salidroside can reduce the inflammatory response caused by ultraviolet rays, repair damaged skin cells, and promote skin regeneration and repair.

Current status of salidroside production

1)Mainly rely on plant extraction

Rhodiola rosea is the raw material of salidroside. As a kind of perennial herbaceous plant, Rhodiola rosea mainly grows in areas with high cold, anoxia, dryness and large temperature difference between day and night at an altitude of 1600-4000 meters. It is one of the wild plateau plants. China is one of the main producing areas of Rhodiola rosea in the world, but the living habits of Rhodiola rosea are quite special. Not only is it difficult to cultivate artificially, but the yield of wild varieties is extremely low. At present, the annual demand gap for Rhodiola rosea is as high as 2,200 tons.

2) Chemical synthesis and biological fermentation

Due to the low content and high production cost in plants, in addition to natural extraction methods, salidroside production methods also include chemical synthesis methods, biological fermentation methods, etc. Among them, as the technology continues to mature, biological fermentation has become the mainstream technology path for the research and development and production of salidroside. At present, Suzhou Mailun has achieved research and development results and has achieved industrialization.

Radiation is an unavoidable part of our daily lives and is frequently used in medical diagnosis and treatment. However, the damage caused by radiation to human tissues and cells cannot be ignored. Therefore, finding efficient, low-toxic or non-toxic radiation protective agents has always been a research hotspot.

Suzhou Myland Nutraceuticals Inc. is an FDA-registered manufacturer that provides high-quality and high-purity Salidroside powder.

At Suzhou Myland we are committed to providing the highest quality products at the best prices. Our Salidroside powder is rigorously tested for purity and potency, ensuring you get a high-quality supplement you can trust. Whether you want to support cellular health, boost your immune system or enhance overall health, our Salidroside powder is the perfect choice.

With 30 years of experience and driven by high technology and highly optimized R&D strategies, Suzhou Myland has developed a range of competitive products and become an innovative life science supplement, custom synthesis and manufacturing services company.

In addition, Suzhou Myland is also an FDA-registered manufacturer. The company's R&D resources, production facilities, and analytical instruments are modern and multifunctional, and can produce chemicals from milligrams to tons in scale, and comply with ISO 9001 standards and production specifications GMP.