Dehydrozingerone (DHZ, CAS:1080-12-2) is one of the active components of ginger and has a similar chemical structure to curcumin. It has been shown to activate AMP-activated protein kinase (AMPK), thereby contributing to beneficial metabolic effects such as improved blood glucose levels, insulin sensitivity and glucose uptake.
Unlike ginger or curcumin, DHZ can significantly improve mood and cognition through serotonergic and noradrenergic pathways. It is a natural phenolic compound extracted from ginger rhizome and is generally recognized as safe (GRAS) by the FDA.
It is structurally similar to its sister compound curcumin, but targets alternative pathways related to mood and metabolism, without the associated bioavailability issues.
The potential role of dehydrozingerone (DHZ) in weight loss is as follows:
Activate AMPK:
Dehydrozingerone activates adenosine monophosphate kinase (AMPK), an enzyme that plays an important role in energy metabolism. When AMPK is activated, it stimulates ATP-generating processes, including fatty acid oxidation and glucose uptake, while reducing energy "storage" activities such as lipid and protein synthesis. Research shows that exercise significantly increases cellular energy needs, and dehydrozingerone can stimulate AMPK without the need for exercise, helping to burn more fat.
Anti-Inflammatory Fat Tissue Blocker:
Dehydrozingerone has anti-inflammatory effects, similar to curcumin, and may be able to prevent the accumulation of fatty tissue.
Studies have shown that dehydrozingerone-fed mice gained less weight and had significantly less lipid accumulation in their livers.
Improve insulin sensitivity:
Dehydrozingerone can activate the glucose uptake protein GLUT4 in skeletal muscle cells, enhance glucose uptake, and thereby improve insulin sensitivity.
This is important to prevent weight gain and improve metabolic function.
Potential anti-aging effects:
The antioxidant and anti-inflammatory effects of dehydrozingerone help reduce free radicals and inflammation, potentially delaying the aging process associated with obesity.
Emotional and mental health support:
Research on the effects of dehydrozingerone on the brain suggests it may help improve mental health and reduce mood problems such as depression and anxiety, thereby helping to maintain healthy eating habits and lifestyle.
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Post time: Oct-21-2024
