What’s N-Boc-O-Benzyl-D-Serine and Why Does It Matter?

In the chemical and pharmaceutical industries, N-Boc-O-benzyl-D-serine is an important amino acid derivative due to its use in the synthesis of bioactive molecules and drugs. It has attracted much attention for its wide application in development."N-Boc" refers to the tert-butoxycarbonyl (Boc) protecting group, which is often used to protect the amino group of amino acids in peptide synthesis. "O-Benzyl" means that a benzyl group is attached to the hydroxyl group of serine, thereby enhancing its stability and solubility.

N-Boc-O-benzyl-D-serine Introduction

N-Boc-O-benzyl-D-serine (CAS:47173-80-8), appears as a white to off-white powder, N- Boc-O-Benzyl-D-serine is a derivative of the amino acid D-serine. Due to its unique structural properties, it plays an important role in chemical synthesis and peptide chemistry. The following is a detailed description of its components: where N-Boc refers to the tert-butoxycarbonyl (Boc) protecting group.

Protecting groups are used in organic synthesis to temporarily shield functional groups, allowing selective reactions without interference from other reaction sites. O-benzyl indicates that the benzyl group is attached to the oxygen of the hydroxyl group of serine. Benzyl is a common aromatic substituent that can affect the solubility and reactivity of compounds. D-serine is one of the two enantiomers of serine and belongs to the methionine family. Serine is an important amino acid for biosynthesis, energy production and intracellular reducing agent production. These processes are crucial for the growth and proliferation of cancer cells.

N-Boc-O-benzyl-D-serine Function Introduction

1. D-serine can reduce symptoms of cognitive decline.

Glutaminergic signaling is known to enhance memory formation because activation of NMDA receptors causes calcium influx and mobilization of calmodulin-dependent kinase (CaMK) and CREB-binding proteins, which act to induce long-term potentiation (LTP ), which forms the basis of the mechanism known as memory, and results in an increase in NMDA signaling (especially through the NR2B subunit) causing an increase in memory and LTP. This is also the memory enhancement mechanism observed with magnesium L-threonate. Because D-serine can enhance signaling through NMDA receptors, paired with the activity of D-serine in this process and the known sensitivity of hippocampal cells to D-serine stimulation, it is believed that supplementing D-serine can promote memory and learning.

2.Research has found that the loss of Menin protein in the hypothalamus is an important factor leading to aging, and supplementing D-serine can improve cognitive impairment in elderly mice.

Studies have found that the hypothalamus also plays a key role in cognitive impairment caused by aging. During the aging process, the Menin protein in the hypothalamus (hereinafter referred to as Menin) will gradually decrease with the aging process, affecting the synthesis of D-serine, further accelerating the aging process and cognitive dysfunction. In addition, D-serine supplementation can significantly improve the aging phenotype and alleviate cognitive impairment in aged mice.

The results of the study showed that after supplementing D-serine, the levels of D-serine in the hypothalamus and hippocampus of the three groups of mice were significantly increased compared with the same kind of mice that were not supplemented with D-serine (p<0.01), and their cognitive status was improved. Significant improvement (p<0.05), indicating that D-serine supplementation may be a treatment option for improving aging-related cognitive impairment.

N-Boc-O-Benzyl-D-Serine vs. Other Amino Acids: What's the Difference?

1. Structural differences

The most obvious difference between N-Boc-O-benzyl-D-serine and other amino acids is its structure. While standard amino acids have a simple backbone consisting of amino groups, carboxyl groups and side chains, N-Boc-O-benzyl-D-serine has additional functional groups that alter its properties.

For example, the Boc group provides protection during peptide synthesis, allowing more complex reactions to be performed without unwanted side reactions. Benzyl groups enhance hydrophobic interactions, thereby affecting the folding and stability of peptides and proteins.

2. Functional features

N-Boc-O-Benzyl-D-Serine exhibits unique functional properties compared to other amino acids. Its D configuration allows it to interact differently with biological systems compared to the more common L configuration found in most proteins. This can lead to changes in biological activity, making it a valuable tool in drug design and development.

In contrast, simpler, more common amino acids such as glycine or alanine do not have the same level of complexity or specificity in their interactions. This makes N-Boc-O-Benzyl-D-Serine particularly useful in studies of neuropharmacology and receptor interactions.

3. Applications in research and medicine

N-Boc-O-Benzyl-D-Serine has attracted attention in various fields, especially in the fields of medicinal chemistry and neurobiology. Its ability to modulate NMDA receptor activity makes it a candidate drug for studying neurological disorders such as schizophrenia and Alzheimer's disease. Researchers are exploring its potential as a therapeutic agent to enhance cognitive function or mitigate neurodegenerative processes.

In contrast, more common amino acids such as leucine or valine have often been studied for their role in muscle metabolism and protein synthesis. While they are essential for overall health and well-being, their targeted applications in neuropharmacology differ from N-Boc-O-Benzyl-D-Serine.

4. Synthesis and Stability

The synthesis of N-Boc-O-benzyl-D-serine involves more complex chemical reactions than standard amino acids. The introduction of protecting groups and the need for specific reaction conditions can make their synthesis more challenging. However, these modifications also enhance its stability, making it suitable for a variety of experimental conditions.

In contrast, standard amino acids are generally readily available and easier to synthesize, but they may not provide the same level of stability or specificity required for advanced research applications.

D-Real-Life Applications of N-Boc-O-Benzyl-D-Serine

Serine plays important physiological functions in the human body, especially the regulation and protection of the nervous system. N-Boc-O-benzyl-D-serine as a serine derivative is an important class of bioactive molecules that is frequently used in peptide synthesis and other organic chemistry applications, especially in the development of drugs and bioactive compounds. The protecting group can be removed under specific conditions to obtain free amino acids or other derivatives for further research or application. Widely used in medical and biological research.

1. Chemical synthesis and peptide chemistry

N-Boc-O-benzyl-D-serine is used as a building block in the chemical synthesis of various compounds and is also a key component in peptide chemistry. Its use in this field is due to its ability to be incorporated into larger molecular structures, aiding the development of new drugs and bioactive molecules.

2. Pharmaceutical industry

N-Boc-O-benzyl-D-serine was used as a precursor for the preparation of substituted naphthodiazolidinones. These compounds act as protein tyrosine phosphatase degraders and have potential therapeutic applications in the treatment of cancer and metabolic diseases. Degradation of these phosphatases helps regulate cell signaling pathways, thereby providing a therapeutic approach to combat these diseases.

3. Research and development

In research and development, N-Boc-O-benzyl-D-serine is used to synthesize new molecules with potential biological activity. Its unique structure allows scientists to explore its properties and applications to create innovative drugs and therapies for a variety of medical conditions.

Where to Buy N-Boc-O-benzyl-D-serine?

As a manufacturer of N-Boc-O-benzyl-D-serine powder, Suzhou Myland has won the trust of many customers with its high-purity products and strict quality control. The company is committed to providing customers with high-quality raw materials and helping them succeed in their respective industries.

1. Reliable product quality

Suzhou Myland's N-Boc-O-benzyl-D-serine powder undergoes multiple tests to ensure its purity and quality meet industry standards. The company has a professional quality inspection team that conducts random inspections of products regularly to ensure the stable quality of each batch of products.

2. Flexible supply capabilities

Whether it is a small batch or a large-scale order, Suzhou Mailun Biotechnology can respond flexibly to ensure that customer needs are met. The company has established a complete logistics system to quickly deliver products to customers.

3. Professional technical support

Suzhou Myland's R&D team is composed of a number of industry experts and can provide customers with professional technical consultation and support to help customers better understand and apply N-Boc-O-benzyl-D-serine.

4. Competitive price

On the premise of ensuring product quality, Suzhou Myland provides competitive prices to help customers reduce procurement costs and improve market competitiveness.

Choosing the right N-Boc-O-benzyl-D-serine supplier is key to ensuring product quality and safety. Suzhou Myland has become a trustworthy choice in the industry with its high-purity products, strict quality control and professional services. Whether you are a pharmaceutical company or a scientific research institution, Suzhou Myland can provide you with high-quality N-Boc-O-benzyl-D-serine powder to assist your research and development. For more details, please visit Suzhou Myland’s official website.