In the world of dietary supplements, magnesium alpha-ketoglutarate powder has received widespread attention for its potential health benefits. This compound is known for its role in energy production, muscle recovery, and overall metabolic health. If you want to incorporate this supplement into your daily routine, it's crucial to know where to buy high-quality magnesium alpha ketoglutarate powder online.
Alpha-ketoglutarate (AKG) has long been a popular sports supplement commonly used in the fitness community, but interest in this molecule has now entered the field of aging research due to its central role in metabolism. AKG is a naturally occurring endogenous intermediary metabolite that is part of the Krebs cycle, meaning our own bodies produce it.
AKG is a molecule involved in many metabolic and cellular pathways. It functions as an energy donor, precursor for amino acid production and cell signaling molecule, and is a regulator of epigenetic processes. It is a key molecule in the Krebs cycle, regulating the overall speed of the organism's citric acid cycle. It works in various pathways in the body to help build muscle and help heal wounds, which is one of the reasons it's popular in the fitness world. Sometimes, health care providers give alpha-ketoglutarate intravenously to prevent heart damage caused by blood flow problems during heart surgery and to prevent muscle loss after surgery or trauma.
AKG also acts as a nitrogen scavenger, preventing nitrogen overload and preventing the accumulation of excess ammonia. It is also a key source of glutamate and glutamine, which stimulate protein synthesis and inhibit protein degradation in muscles. Furthermore, it regulates eleven translocation (TET) enzymes involved in DNA demethylation and the Jumonji C domain containing lysine demethylase, the major histone demethylase Enzymes. In this way, it is an important player in gene regulation and expression.
【Can AKG delay aging? 】
There is evidence that AKG can affect aging, and many studies show that it does. One study showed that AKG extended the lifespan of adult C. elegans by approximately 50% by inhibiting ATP synthase and the target of rapamycin (TOR). In this study, AKG was found to not only extend lifespan but also delay certain age-related phenotypes, such as the loss of rapid coordinated body movements common in older C. elegans worms.
【ATP synthase】
Mitochondrial ATP synthase is a ubiquitous enzyme involved in energy metabolism in most living cells. ATP is a membrane-bound enzyme that serves as an energy carrier to promote cellular energy metabolism. Research in 2014 showed that in order to extend the lifespan of C. elegans, AKG requires ATP synthase subunit beta and relies on downstream TOR. Researchers found that ATP synthase subunit β is a binding protein of AKG. They found that AKG inhibits ATP synthase, leading to a decrease in available ATP, a decrease in oxygen consumption, and an increase in autophagy in both nematode and mammalian cells.
The direct binding of ATP-2 by AKG, the associated enzyme inhibition, reduction in ATP levels, reduction in oxygen consumption and extension of lifespan are almost identical to those when ATP synthase 2 (ATP-2) is directly genetically knocked out. Based on these findings, the researchers concluded that AKG may extend lifespan by targeting ATP-2. Essentially, what's happening here is that mitochondrial function is somewhat inhibited, specifically the electron transport chain, and it's this partial inhibition that leads to the extended lifespan of C. elegans. The key is to reduce mitochondrial function enough without going too far or it becomes harmful. Therefore, the saying "live fast, die young" is absolutely true, only in this case, due to the inhibition of ATP, the worm can live slow and die old.
[Alpha-ketoglutarate and target of rapamycin (TOR)]
Various studies have shown that inhibition of TOR can affect aging in a variety of species, including slowing down aging in yeast, slowing down aging in Caenorhabditis elegans, slowing down aging in Drosophila, and regulating lifespan in mice. AKG does not interact directly with TOR, although it does affect TOR, primarily by inhibiting ATP synthase. AKG relies, at least in part, on activated protein kinase (AMPK) and forkhead box "other" (FoxO) proteins to influence lifespan. AMPK is a conserved cellular energy sensor found in multiple species, including humans. When the AMP/ATP ratio is too high, AMPK is activated, which inhibits TOR signaling by activating the phosphorylation of the TOR inhibitor TSC2. This process enables cells to efficiently regulate their metabolism and balance their energy status. FoxOs, a subgroup of the forkhead transcription factor family, play a critical role in regulating the effects of insulin and growth factors on multiple functions, including cell proliferation, cell metabolism, and apoptosis. One study shows that to extend lifespan by reducing TOR signaling, the FoxO transcription factor PHA-4 is required.
【α-ketoglutarate and autophagy】
Finally, autophagy activated by caloric restriction and direct inhibition of TOR was significantly increased in C. elegans given additional AKG. This means that AKG and TOR inhibition increase lifespan through the same pathway or through independent/parallel pathways and mechanisms that ultimately converge on the same downstream target. This is further supported by studies on starved yeast and bacteria, as well as humans after exercise, which showed increased AKG levels. This increase is thought to be a starvation response, in this case compensatory gluconeogenesis, which activates glutamate-related transaminases in the liver to produce carbon from amino acid catabolism.
Magnesium is the fourth most abundant mineral in the human body and participates in more than 300 enzymatic reactions. It is essential for energy production, protein synthesis, muscle contraction, and nerve function. Magnesium also maintains normal heart rhythm and regulates blood pressure.
Although magnesium is important, many people do not consume adequate amounts of it, resulting in a magnesium deficiency that affects overall health. Common dietary sources of magnesium include green leafy vegetables, nuts, seeds, whole grains and legumes.
Interaction between magnesium and alpha-ketoglutarate
1. Enzymatic reaction
Magnesium ions are essential for the activity of various enzymes involved in the Krebs cycle, including the enzyme that converts alpha-ketoglutarate to succinyl-CoA. This conversion is critical for the continuation of the Krebs cycle and the production of ATP, the cellular energy currency.
Without enough magnesium, these enzymatic reactions may be impaired, leading to reduced energy production and potential metabolic dysfunction. This highlights the importance of maintaining adequate magnesium levels for optimal cell function and energy metabolism.
2. Regulation of metabolic pathways
Magnesium also plays a role in regulating metabolic pathways involving alpha-ketoglutarate. For example, magnesium affects the activity of amino acid metabolism enzymes closely related to AKG. The conversion of certain amino acids into α-ketoglutarate is a key step in energy production and nitrogen metabolism. In addition, magnesium has been shown to regulate the activity of key signaling pathways, such as the mTOR pathway involved in cell growth and metabolism. By affecting these pathways, magnesium can indirectly affect the levels and utilization of alpha-ketoglutarate in the body.
3. Antioxidant properties
Alpha-ketoglutarate is known for its antioxidant properties, helping to reduce oxidative stress within cells. Magnesium has also been shown to have antioxidant effects. When magnesium is present in sufficient amounts, it enhances the antioxidant capabilities of alpha-ketoglutarate, providing additional protection against oxidative damage. Oxidative stress has been linked to a variety of health problems, including chronic disease and aging. By supporting the antioxidant functions of alpha-ketoglutarate, magnesium may contribute to cellular health and longevity.
Magnesium alpha-ketoglutarate is a compound that combines magnesium with alpha-ketoglutarate, a key intermediate in the Krebs cycle (also known as the citric acid cycle), which is essential for cells energy production is crucial. Often used in dietary supplements due to its potential benefits in enhancing athletic performance, recovery and overall metabolic health.
1. Enhance energy production
One of the main benefits of Magnesium Alpha Ketoglutarate Powder is its ability to increase energy levels. AKG plays a vital role in the Krebs cycle, which is responsible for converting nutrients into energy. By supplementing with AKG, you support your body's energy production process. Additionally, magnesium is essential for the production of ATP (adenosine triphosphate), the cell's energy currency.
2. Improve muscle function and recovery
Magnesium is known for its role in muscle contraction and relaxation, which is essential for optimal performance. AKG can also help reduce muscle soreness and shorten recovery time after an intense workout. By incorporating this supplement into your daily routine, you may experience increased endurance, reduced fatigue, and faster recovery, allowing you to push your limits.
3. Cognitive Support
Cognitive health is a growing concern for many people, especially as we age. Research suggests AKG may have neuroprotective properties that may help support brain health and cognitive function. Magnesium also plays a role in neurotransmitter regulation, which is critical for mood and cognitive performance. By combining these two compounds, magnesium alpha ketoglutarate powder may help improve focus, memory, and overall mental clarity.
4. Support healthy aging
As we age, our bodies undergo various changes that can affect our health. Supplementing with magnesium alpha ketoglutarate powder may help reduce some of these effects. Animal studies have linked AKG to increased longevity, and its ability to support cellular health may contribute to a healthier aging process. Magnesium, on the other hand, is essential for maintaining bone density and preventing age-related diseases. Together, they can promote a healthier, more energetic life as we age.
5. Enhance immune function
A strong immune system is vital to overall health, especially in today's world. Magnesium plays a vital role in immune function, helping to regulate inflammation and support the body's defense mechanisms. AKG may also have immune-boosting properties, making this combination a powerful ally in maintaining a healthy immune response.
While the basic ingredients of alpha-ketoglutarate and magnesium may be similar in different supplements, several factors can affect their effectiveness and quality. Here are some key considerations:
1.Dosage form and dosage
Not all AKG magnesium supplements are created equal. Formulations can vary greatly between brands. Some may contain other ingredients, such as vitamins, minerals, or herbal extracts, that can enhance or alter the effects of the main ingredient.
2. Bioavailability
Bioavailability refers to the extent and rate at which a substance is absorbed into the bloodstream. Some forms of magnesium, such as magnesium citrate or magnesium glycinate, are more bioavailable than other forms of magnesium, such as magnesium oxide. The form of magnesium used in a supplement can significantly affect how well your body utilizes it.
Likewise, the form of alpha-ketoglutarate affects its absorption. Look for supplements that use high-quality, bioavailable forms of both compounds to ensure you get the maximum benefit.
3. Purity and Quality
The purity and quality of the ingredients used in a supplement are critical to its effectiveness and safety. Some products may contain fillers, additives, or contaminants that may reduce their effectiveness or pose health risks. When choosing an AKG magnesium supplement, look for products that have been third-party tested for purity and quality. Certification from organizations such as NSF International or the United States Pharmacopeia ensures that products meet high standards.
4. Brand reputation
Brand reputation also plays an important role in the quality of supplements. Well-known brands with a history of producing high-quality products are often more reliable than newer or less well-known companies. Research customer reviews and ratings to gauge the effectiveness and reliability of your brand's products.
5. Intended use
When choosing an AKG magnesium supplement, consider your specific health goals. Are you looking to enhance athletic performance, support muscle recovery or improve overall health? Different formulations may be better suited for different purposes.
In modern nutrition and biomedical research, α-ketoglutarate magnesium powder has attracted more and more attention as an important dietary supplement raw material. Not only does it play a key role in energy metabolism, it is also thought to have a positive impact on cell growth, repair and anti-aging. In order to meet the needs of scientific research and health supplement markets, it is particularly important to choose high-quality Alpha Ketoglutarate Magnesium Powder.
Suzhou Myland is an enterprise specializing in the research, development and production of dietary supplement raw materials. It is committed to providing customers with high-purity α-ketoglutarate magnesium powder. The CAS number of this product is 42083-41-0, and its purity is as high as 98%, ensuring its reliability and effectiveness in various experiments and applications.
Features
High purity: The purity of Suzhou Myland α-ketoglutarate magnesium powder reaches 98%, which means that users can obtain more accurate and consistent experimental results during use. High-purity products can effectively reduce the interference of impurities on experiments and ensure the rigor of research.
Quality Assurance: As a biotechnology company with rich experience, Suzhou Myland strictly follows international standards for production and quality control. Each batch of products undergoes rigorous testing to ensure that it meets relevant quality standards. Customers can use it with confidence and reduce risks caused by product quality problems.
Multiple functions: Magnesium α-ketoglutarate powder not only plays an important role in energy metabolism, but is also widely used in sports nutrition, anti-aging, cell protection and other fields. Research shows that AKG can promote the synthesis of amino acids, enhance muscle recovery capabilities, and delay the aging process to a certain extent.
Easy to absorb: As an important mineral, magnesium is essential for many physiological functions of the human body. When combined with alpha-ketoglutarate, the bioavailability of magnesium is increased, allowing users to supplement magnesium while also reaping the multiple benefits of AKG.
Purchase channels
Suzhou Myland provides convenient online purchasing channels. Customers can obtain a more detailed understanding through the official website. In addition, the company's professional team will also provide customers with technical support and consulting services to help customers better understand and use the products.
When looking for high-quality magnesium alpha-ketoglutarate powder, Suzhou Myland is undoubtedly a trustworthy choice. With its high purity, strict quality control and wide application prospects, Suzhou Myland products can meet the various needs of scientific researchers and enterprises. Whether you are conducting basic research or developing new products, you can get high-quality protection and support by choosing Suzhou Myland magnesium alpha-ketoglutarate powder.
Q:What is Magnesium Alpha-Ketoglutarate Powder?
A:Magnesium Alpha-Ketoglutarate Powder is a dietary supplement that combines magnesium with alpha-ketoglutarate, a compound involved in the Krebs cycle, which is essential for energy production in the body. This supplement is often used to support metabolic health, enhance athletic performance, and promote overall well-being.
Q: What are the benefits of taking Magnesium Alpha-Ketoglutarate Powder?
A:Some potential benefits of Magnesium Alpha-Ketoglutarate Powder include:
●Enhanced Energy Production: Supports the Krebs cycle, aiding in the conversion of nutrients into energy.
●Muscle Recovery: May help reduce muscle soreness and improve recovery time after exercise.
●Bone Health: Magnesium is essential for maintaining healthy bones and may help prevent osteoporosis.
Cognitive Function: Some studies suggest it may support brain health and cognitive function.
●Metabolic Support: Can assist in regulating metabolic processes and may help with weight management.
Disclaimer: This article is for general information only and should not be construed as any medical advice. Some of the blog post information comes from the Internet and is not professional. This website is only responsible for sorting, formatting and editing articles. The purpose of conveying more information does not mean that you agree with its views or confirm the authenticity of its content. Always consult a health care professional before using any supplements or making changes to your health care regimen.
Post time: Oct-12-2024
