Palmitoylethanolamide (PEA Granule) powder manufacturer CAS No.: 544-31-0 97% purity min. for supplement ingredients

 Palmitoylethanolamide is a lipid messenger molecule first discovered in the late 1950s. It belongs to a class of compounds called endocannabinoids, which are natural substances that interact with the body’s endocannabinoid system. Unlike other cannabinoids such as THC found in the cannabis plant, PEA is non-psychoactive and does not produce any mind-altering effects. The endocannabinoid system (ECS) is a complex network of receptors and endocannabinoids found throughout the body. It plays a critical role in regulating a variety of physiological processes, including pain perception, inflammation, and mood.  PEA serves as an endogenous ligand for a specific receptor within the ECS called peroxisome proliferator-activated receptor-α (PPAR-α). By activating this receptor, PEA exerts its anti-inflammatory and analgesic effects. Studies show that Palmitoylethanolamide can help manage chronic pain, including neuropathic and inflammatory pain. It works by reducing the release of pro-inflammatory substances and regulating the activation of immune cells involved in the inflammatory response. Multiple clinical trials have demonstrated the efficacy of PEA in reducing pain intensity and improving quality of life in patients with a variety of chronic pain conditions.